objective(s) the purpose of the present study was to use the solid dispersion (sd) technique to improve the dissolution rates of indomethacin (imc). materials and methods imc solid dispersions in pvp k30 and isomalt (galen iq 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (imc:pvp). solid dispersions and physical mixtures were ...

the solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. fused dispersions (fds) of simvastatin (sim) using peo-ppo block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. the accumulative solub...

it has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. in order to improve the bioavailability, the release behavior of such drugs should be improved. although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...

    The solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. Fused dispersions (FDs) of simvastatin (SIM) using PEO-PPO block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. The accumulative s...

    The solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. Fused dispersions (FDs) of simvastatin (SIM) using PEO-PPO block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. The accumulative s...

Objective(s) The purpose of the present study was to use the solid dispersion (SD) technique to improve the dissolution rates of indomethacin (IMC). Materials and Methods IMC solid dispersions in PVP K30 and isomalt (GALEN IQ 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (IMC:PVP). Solid dispersions and physical mixtures we...

The purpose of this study was to develop a compaction technique to enhance the solubility, dissolution rate and other physicochemical properties of poorly water-soluble drug indomethacin (IM) with different polymers. The IM was compacted with the different polymers like hydroxy propyl methylcellulose (HPMC), Kollicoat IR, Chitosan, Polyvinyl Pyrrolidone without using any binder and solvent. Pol...